Non Animal Testing Database

In vitro model to study the capacities of regulating T cells

Queen Mary University London, London, United Kingdom
Regulatory T-cells (Treg) are a subset of T-cells that suppress effector T-cell immune responses. Cellular therapy with antigen-specific Treg has the potential to selectively control unwanted T-cell immune responses that mediate a range of pathologies. Ex vivo expansion of Treg and graft back to the patient has been in use but the stability of these cells is poorly known. In the present study, the researchers used an in vitro model to expand and scrutinize human Treg first obtained from human donors. The functional stability and migratory capacity of these cells was assessed in various proinflammatory conditions in in vitro model to simulate the effects of the posttransplantation environment. The expanded Treg cells retained their phenotype and function, yet lost some of their migratory capacity. The findings underline that better characterization of cells expanded ex vivo is needed to improve chances of success after transplantation.
Allospecific Tregs expanded after anergization remain suppressive in inflammatory conditions but lack expression of gut-homing molecules
Jeff K Davies
Added on: 10-29-2021
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