Cancer-associated fibroblasts have been described to be related to cancer development and progression. However, little is known about the effect of cancer-associated fibroblasts autophagy on triple-negative breast cancer cells. Here, human fibroblasts from patients with invasive triple-negative breast cancer were co-cultured with human triple-negative breast cancer cells to evaluate the effect of fibroblast autophagy on cancer cell growth. The results showed that cancer-associated fibroblasts had significantly higher levels of autophagy-related proteins. Moreover, cancer-associated fibroblasts conditioned media induced metastatic behaviour and changes in the levels of vimentin, N- and E-cadherin in triple-negative breast cancer cells. Finally, key proteins in the Wnt/beta-catenin pathway were upregulated in conditioned media treated cells. Overall, the researchers demonstrate that cancer-associated fibroblasts autophagy increases metastatic features in triple-negative breast cancer cells and upregulates epithelial-to-mesenchymal transition through Wnt/beta-catenin, opening new possibilities in the development of cancer targets.
Cancer-associated fibroblasts autophagy enhances progression of triple-negative breast cancer cells
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