Non Animal Testing Database

Biopsies to study the role of stem cells in salivary gland disease

Sjögren's syndrome (SS) is an autoimmune disease affecting around 3 million people in the US alone, predominantly women. A major characteristic of the disease is salivary gland (SG) hypofunction. In the present study, the researchers looked at the inability of resident SG stem cells (SGSCs) to maintain homeostasis and saliva production in the glands. SGSCs were isolated from parotid biopsy samples from patients. In vitro assays were done to assess self-renewal and differentiation: transcription analysis, single telomere length analysis and immunohistochemical analysis. The researchers show that SGSCs from diseased patients are lower in number, less able to differentiate and in a more senescent stage. The results demonstrate for the first time a link between autoimmune disease and a premature-ageing phenotype and give hints to the kind of therapeutics to be developed.
Salivary gland stem cells age prematurely in primary Sjögren's syndrome
Added on: 10-18-2021
Back to Top
English German
Lush Prize Winner 2022Lush Prize Winner 2022
Winner of the Animal Protection Prize of Lower Saxony 2022Winner of the Animal Protection Prize of Lower Saxony 2022

Warning: Internet Explorer

The IE from MS no longer understands current scripting languages, the latest main version (version 11) is from 2013 and has not been further developed since 2015.

Our recommendation: Use only the latest versions of modern browsers, for example Google Chrome, Mozilla Firefox or Microsofrt Edge, because only this guarantees you sufficient protection against infections and the correct display of websites!