Computational study of inflammatory pathways in neurodegeneration
2018
University of Luxembourg, Luxembourg, Luxembourg
An analysis of post-mortem brains affected by Alzheimer's disease has shown a clear involvement of inflammation in the pathology of the disease. Here, a new computational approach is used to study six neuronal populations from Alzheimer's patients. The goal of this method is to identify signalling pathways that might be activated or inhibited during the pathology progress and which result in neurotoxicity. With this method, the researchers were able to describe several altered inflammatory mediators, with a considerable amount of region-specificity among them. In summary, this computational method could identify inflammatory pathways that may have a key role in the development of Alzheimer's disease and can be a powerful tool to translate omics data into therapeutical approaches.
Integrative computational network analysis reveals site-specific mediators of inflammation in Alzheimer's disease
Antonio Del Sol
Added on: 08-06-2021
[1] https://www.frontiersin.org/articles/10.3389/fphys.2018.00154/full[2] https://data.jrc.ec.europa.eu/dataset/a8fd26ef-b113-47ab-92ba-fd2be449c7eb
