Mathematical model of pathological calcium signalling in neuronal death
2018
Nanyang Technological University, Singapore, Singapore
Amyloid-beta accumulation leads to disturbed calcium signalling in neurons in Alzheimer's disease, leading to apoptosis. Here, a mathematical model is presented that combines models of amyloid deposition, calcium signalling and mitochondrial permeability transition pore-related cell apoptosis in Alzheimer's disease. Results show that without amyloid deposition, calcium levels remain at resting concentration, while in the simulated pathological situation there is an intracellular dysregulation of calcium ions and channels. This mathematical model allows the study of potential calcium-related pathological mechanisms in Alzheimer's disease that are not easily accessible experimentally.
Composite mathematical modeling of calcium signaling behind neuronal cell death in Alzheimer’s disease
Jie Zheng
Added on: 08-05-2021
[1] https://bmcsystbiol.biomedcentral.com/articles/10.1186/s12918-018-0529-2[2] https://data.jrc.ec.europa.eu/dataset/a8fd26ef-b113-47ab-92ba-fd2be449c7eb
