Pathways monitored in prognostic signature of breast cancer subtypes
2017
Toronto General Research Institute—University Health Network, Toronto, Canada(1)
University of Toronto, Toronto, Canada(2)
University of Toronto, Toronto, Canada(2)
Validation in human breast tumor is performed in samples of a 17-gene prognostic signature for HER2 enriched tumor-initiating cells. The main objective of this study is to identify the biological pathways that monitor the prognostic genes. With a series of computational methods and human tumor samples, it is shown that the main pathways involved correspond to cell proliferation, immune response and cell migration. Additionally, it identifies substitutes and 6 core genes that would facilitate the clinical implementation of this method.
Identification of cell proliferation, immune response and cell migration as critical pathways in a prognostic signature for HER2+:ERα- breast cancer
Jeffrey C Liu(1), Eldad Zacksenhaus(2)
Added on: 08-01-2021
[1] https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0179223[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
