Scaffold influence in a 3D model of breast cancer metastasis
November 2016
University of Pittsburgh, Pittsburgh, USA
A 3D model is used to study the influence of scaffold properties in human breast cancer metastatic cells. When mixed in softer hydrogel scaffolds with hepatic tissue, metastatic cells were more prone to acquire dormant profiles and were more responsive to inflammatory stimuli, while hepatic cells were less pro-inflammatory. Additionally, dormant cells вев more responsive to certain doses of chemotherapy. This shows the potential improvements that this model can bring to personalized therapeutic strategies to target dormant metastatic breast cancer cells.
A liver microphysiological system of tumor cell dormancy and inflammatory responsiveness is affected by scaffold properties
Alan Wells
Added on: 07-29-2021
[1] https://pubs.rsc.org/en/content/articlelanding/2017/lc/c6lc01171c[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
