Human embryo stem cells commit to specialization surprisingly early
2020
The Francis Crick Institute, London, United Kingdom
Working with human embryonic stem cells and mathematical models, a new class of genes was identified, which are responsible for regulating one of the earliest stages of human development. Once these GATA3-genes are activated experimentally, embryonic stem cells are quickly committed to differentiation. Additionally they trigger a positive feedback loop, which helps them stay active. In turn, this ensures that the cells remain differentiated, and do not switch back into stem cell state. Stem cells were derived from embryos donated by people undergoing IVF. The donated embryos were obsolete during fertility treatments and would have been wasted.
GATA3 mediates a fast, irreversible commitment to BMP4-driven differentiation in human embryonic stem cells
Santos, Silvia D.M.
Added on: 05-14-2020
[1] https://www.sciencedirect.com/science/article/abs/pii/S1934590920300977?via%3Dihub[2] https://www.technologynetworks.com/cell-science/news/stem-cells-in-human-embryos-commit-to-specialization-surprisingly-early-333649
