Human lung cell model with an air-liquid-interface in a reactor for toxicity testing
2017
Cultex Technology, Hanover, Germany
Human lung epithelial cells obtained during surgery are cultivated on a special membrane, over a nutrient medium. From the other side the cells are exposed to aerosols, directed over their surface. This simulates an air-liquid interface similar to that of the human lung. Via the exposure modules, these cell cultures can be vital for weeks. The exposure module directs a substance-bearing air stream over the cells, which is aspirated via a vacuum pump so that a continuous flow is created. This model enables the analysis of acute and chronic toxicity of substances, as well as of the lung cell repair mechanisms.
Improvement of the CULTEX® exposure technology by radial distribution of the test aerosol
Michaela Aufderheide
Added on: 04-21-2020
[1] https://www.sciencedirect.com/science/article/abs/pii/S0940299317300544?via%3Dihub[2] https://www.cultex-technology.com/
