Sorption of drugs in organs-on-a-chip
2025
Cellbox Labs, Riga, Latvia
The study investigates how small drug molecules are absorbed and released by materials used in microfluidic systems, known as organs-on-chips. In particular, it compares how these substances behave in two materials: PDMS (polydimethylsiloxane) and COC (cyclic olefin copolymer).
Therefore, drug compounds were absorbed in the materials, and HPLC-MS was used to test how much remained in the materials and how much was released again. Experiments were conducted under both static conditions (without flow) and dynamic conditions (with fluid flow). It was found that PDMS strongly absorbs and retains lipophilic molecules, while COC shows significantly less sorption and releases the substances more quickly.
This study demonstrates that the choice of material in microfluidic devices can significantly affect the accuracy of drug testing. Materials with lower sorption, such as COC, are better suited to obtaining reliable test results.
Sorption and release of small molecules in PDMS and COC for Organs on chip
Roberts Rimsa
Added on: 05-15-2025
[1] https://www.nature.com/articles/s41598-025-97111-2
