Drug-induced toxicity in renal organoids
2023
Jena University Hospital, Jena, Germany
During drug development, potential compounds may exhibit unexpected nephrotoxic effects, which imposes a significant financial burden on pharmaceutical companies. As a result, there is an ongoing need for more accurate model systems. Here, the researchers established an accessible approach for an overview of renal organoid histology. Furthermore, they investigated the potential of renal organoids to model responses to drug toxicity. For this purpose, organoids were treated with the chemotherapeutic agent doxorubicin for 48 h. The organoids demonstrated a significant, dose-dependent decline in response to the treatment. This study provides a straightforward experimental framework for drug toxicity assessment in renal organoids that may be used in early research stages to assist screen for potential adverse effects of compounds.
A proof-of-concept assay for quantitative and optical assessment of drug-induced toxicity in renal organoids
Jasmin Dilz, Ralf Mrowka
Added on: 04-02-2024
[1] https://www.nature.com/articles/s41598-023-33110-5
