Mathematical model of fluid flow in organ-chips
October 2023
University of Minho, Guimarães, Portugal
The aim of this study is to develop a numerical model capable of reproducing the fluid flow behaviour within an organ-on-a-chip (OoC) system. Therefore, the validation of a numerical model for an OoC microfluidic device was undertaken. This comprised the assessments of microparticles flowing through a physical OoC model. High-speed microscopy images of the flow, using a blood analogue fluid, were analysed and compared with the numerical simulation. Furthermore, oxygen transport was simulated and evaluated for different Reynolds numbers.
The results predicted by the numerical model and the ones outputted by the experimental model were in good agreement. The successful validation of the numerical model against experimental data shows its accuracy and reliability in simulating the fluid flow within the OoC. This can expedite the OoC design process.
Numerical evaluation and experimental validation of fluid flow behavior within an organ-on-a-chip model
Violeta Carvalho
Added on: 12-02-2023
[1] https://www.sciencedirect.com/science/article/pii/S0169260723005497?via%3Dihub
