In silico development of a vaccine against Candida infection
2022
Shanghai Jiao Tong University, Shanghai, China
To date, no effective therapy is available for Candida auris infections, which especially affect COVID-19 patients. The aim of this study was to characterize therapeutic targets and design vaccine candidates by solely using in silico methods. Therefore, outer membrane proteins, which are considered highly antigenic and essential for host-pathogen interactions, were investigated. The selected proteins were used to predict cytotoxic T lymphocyte and B-cell epitopes, and to design vaccines against C. auris. In particular, subtractive proteomics and immune-informatics approaches were used. The designed candidate vaccines were further evaluated using molecular docking, and immune simulation strategies.
The present study provides new and valuable epitope candidates and prompts future vaccine development against this pathogen.
Subtractive proteomics assisted therapeutic targets mining and designing ensemble vaccine against Candida auris for immune response induction
Dong-Qing Wei, Yanjing Wang
Added on: 09-25-2023
[1] https://www.sciencedirect.com/science/article/pii/S0010482522002542#sec2
