In chemico skin sensitisation
Regulatory accepted 2022
OECD Guidelines for the Testing of Chemicals, Paris, France
This Test Guideline provides an in chemico procedure to discriminate between skin sensitisers and non-sensitisers. The DPRA (Direct Peptide Reactivity Assay) addresses the molecular initiating event (protein reactivity) leading to skin sensitisation by quantifying the reactivity of test chemicals. Three test methods are currently included: Direct Peptide Reactivity Assay (DPRA), Amino Acid Derivative Reactivity Assay (ADRA) and the kinetic Direct Peptide Reactivity Assay (kDPRA). Validated and regulatory accepted under OECD test No. 442C.
In chemico skin sensitisation assay
OECD
Added on: 08-04-2022
[1] https://www.oecd-ilibrary.org/environment/test-no-442c-in-chemico-skin-sensitisation_9789264229709-en
